Keratin, type II cytoskeletal 2 epidermal II (cytokeratin-2) contributes to terminal cornification. Cytokeratin-2 is associated with keratinocyte activation, proliferation and keratinization. Defects in cytokeratin-2 are a cause of ichthyosis bullosa of siemens (IBS). IBS is a rare autosomal dominant disorder displaying a type of epidermolytic hyperkeratosis characterized by extensive blistering from birth.
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human cytokeratin-2.
- Isotype: Rabbit Ig
- Gene: P35908
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blotting (WB)
