Product & ReviewsAntibodies
CyFlow™ Granzyme B Purified
Product Details
- Cat. No.
- CC765505
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly α-tubulin, leading to perturbation of microtubule networks during the induced cell death.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Non-Human Primate
- Antigen: Granzyme B
- Clone: CLB-GB11
- Conjugate: Purified
- Isotype: IgG1
Handling
- Quantity: 0.1 mg
- Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
- Buffer: The reagent is provided in Tris buffered saline (TBS) solution, pH ≈8.0, containing 0.1% (w/v) sodium azide.
Applications
- Flow Cytometry (FC)