Product & ReviewsAntibodies
CyFlow™ CD33 PerCP
Product Details
- Cat. No.
- BE820817
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Non-Human Primate
- Antigen: CD33
- Clone: WM53
- Conjugate: PerCP
- Isotype: IgG1
Handling
- Quantity: 100 tests
- Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
- Buffer: The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
Applications
- Flow Cytometry (FC)
- Immunocytochemistry (ICC)
- Immunohistochemistry (Formalin-Fixed Sections) (IHC (F))
- Immunoprecipitation (IP)
- Western Blotting (WB)