Product & ReviewsAntibodies
CyFlow™ CD105 APC
Product Details
- Cat. No.
- BG489749
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonizes the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Rat
- Antigen: CD105
- Clone: MEM-226
- Conjugate: APC
- Isotype: IgG2a
Handling
- Quantity: 100 tests
- Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
- Buffer: The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
Applications
- Flow Cytometry (FC)
- Immunoprecipitation (IP)
- Western Blotting (WB)