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CD62 antigen-like family member E (CD62E) is a cell-surface glycoprotein that plays a role in immunoadhesion. CD62E mediates the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. CD62E is also involved in capillary morphogenesis. A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).