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The CD235a (HI264) antibody recognizes glycophorin-A (GPA), a single-pass membrane sialoglycoprotein. CD235a is the carrier of blood group M and N specificities, which provide the cells with a large mucin-like surface acting as a barrier to cell fusion by minimizing aggregation between red blood cells in the circulation. CD235a is also a membrane inhibitor of reactive lysis. CD235a is expressed on early erythroblasts, late erythroblasts, erythroblasts, mature erythrocytes and the cells of erythroid cell lines K562 and HEL, but not on all other cells. Mature erythrocytes are CD235a positive but CD45 and CD71 negative. CD235a is a receptor for influenza virus, Plasmodium falciparum EBA-175 and hepatitis A virus. The CD235a (HI197) antibody recognizes papain-sensitive epitopes located in the extracellular specific domain of CD235a, and therefore agglutinating papain-treated cells.