IF image of mouse skin tissue using anti-CD133 (FITC) (1:100)
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CD133; also called Prominin-1; is a product of a single-copy gene on chromosome 4 (4p15.33) in human or chromosome 5 (5b3) in mice. Human CD133 is a transmembrane glycoprotein of 865 amino acids with a total molecular weight of 120 kDa. This protein consists of an N-terminal extracellular domain; five transmembrane domains with two large extracellular loops; and a 59 amino acids cytoplasmic tail [4]. It is selectively localized in microvilli and other plasma membrane protrusions [5;6]. In general; CD133 positive and CD133 negative cells display different characters.
