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Can be used to discriminate between malignant cutaneous melanoma and nevocellular nevi. PAL-M1 recognizes the transferrin receptor (TFR, CD71), a marker for tumor progression in the melanocytic lineage and stains the majority of primary melanomas and their metastases. Local staining of dysplastic nevocellular nevi may be observed. Common nevocel­lular nevi rarely stain. Excellent marker for neoplastic progression of melanocytic proliferation. Reactivity on cultured cell lines: Melanoma cell lines Mel 57, CM 136, M14, BLM; HepG2, PLC, Daudi, Raji, PBLPositive control: Human Melanoma.