Anti-Rat ICAM-1 (Clone 141011)
Product Details
- Cat. No.
- I-682-25 µg
- Clonality
- Monoclonal
- Host
- Mouse
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Description
ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Rat
- Antigen: CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
- Clone: 141011
- Conjugate: Purified No Carrier Protein
- Isotype: IgG2a
- Gene: 25464
Handling
- Quantity: 25 µg
- Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Applications
- Immunoprecipitation (IP)
- Western Blotting (WB)