Product & ReviewsAntibodies

Anti-Mouse TIMP-1

Product Details

Cat. No.
T463- 500 µg
Clonality
Monoclonal
Host
Rat
Leinco Technologies

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Description

Tissue Inhibitor of Metalloproteinases 1, also known as TIMP1 is a widely expressed, secreted protein that functions primarily to inhibit members of a large family of metalloproteinases (MPs). Because of the ability of TIMP-1 to inhibit MPs, it functions in many of the same pathophysiological processes as these enzymes, e.g. wound healing, ovulation, angiogenesis, and cancer cell metastasis. TIMP-1 can also stimulate proliferation and cellular anabolic processes.1 TIMP-1 is a novel negative regulator of HGF activity during liver regeneration.2 Overexpression of TIMP-1 could promote renal interstitial fibrosis through the inflammatory pathway, which might be partly induced by upregulating ICAM-1.3

Biological Information

  • Clonality: Monoclonal
  • Host: Rat
  • Reactivity: Mouse
  • Clone: 151624
  • Conjugate: Purified No Carrier Protein
  • Isotype: IgG2a
  • Gene: 21857

Handling

  • Quantity: 500 µg
  • Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Applications

  • ELISA (ELISA)
  • Immunohistochemistry (IHC)
  • Neutralization (Neut)
  • Western Blotting (WB)
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