Product & ReviewsAntibodies

Anti-Mouse IFNβ - Purified <i>In vivo </i>GOLD™ Functional Grade

Product Details

Cat. No.
I-439-1.0 mg
Clonality
Monoclonal
Leinco Technologies

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Description

Interferons (IFN) consist of two classes. The type I IFN class consists of 20 highly similar IFN-α proteins and a single IFN-ß protein. The second class, type II IFN, consists of a single protein, IFN-γ. IFN-α and IFN-ß signal through the same cell surface receptor IFNAR1 and have a similar range of biological activities including antiviral and antiproliferative activity. The type I IFNs also influence activation, growth and differentiation of T cells, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. IFN-ß has recently proven to be beneficial in patients with multiple sclerosis and could also be a potential therapy for rheumatoid arthritis. It is unclear what cellular mechanisms are involved in IFN-ß’s therapeutic effects, but they may be caused by a restoration of balance between pro- and anti-inflammatory cytokines.

Biological Information

  • Clonality: Monoclonal
  • Reactivity: Mouse
  • Antigen: Fibroblasts & epithelial cells
  • Clone: MIB-5E9.1
  • Conjugate: GOLD, Low Endotoxin Functional Formulation
  • Isotype: IgG
  • Gene: 15977/a>

Handling

  • Quantity: 1.0 mg
  • Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Applications

  • Western Blotting (WB)
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