Product & ReviewsAntibodies

Anti-Mouse CCL21 - (Clone 59106)

Product Details

Cat. No.
C1421-100 µg
Clonality
Monoclonal
Host
Rat
Leinco Technologies

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Description

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7. In the cancer biology CCL21 seems to have multifaceted roles. CCL21 attracts CCR7 bearing cells especially T and dendritic cells but also various cancer cells. Besides the antitumour role as leukocyte recruiting, CCL21 has been shown to facilitate dendritic cell functions and to exert an angiostatic effect. Human and mouse 6Ckine are highly conserved, exhibiting 86% amino acid sequence identity.

Biological Information

  • Clonality: Monoclonal
  • Host: Rat
  • Reactivity: Mouse
  • Clone: 59106
  • Conjugate: Purified No Carrier Protein
  • Isotype: IgG2b

Handling

  • Quantity: 100 µg
  • Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Applications

  • ELISA (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blotting (WB)
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