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Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and D40. Human D45 and its mouse homologue ICAD are the inhibitors of CPAN/D40 and CAD, respectively. Upon cleavage of D45/ICAD by activated caspase, D40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/D40, which causes DNA degradation, is the hallmark of apoptotic cell death.