SelectScience
  • (Opens in new tab)
  • (Opens in new tab)
  • (Opens in new tab)
Join Free
  1. Home
  2. /Antibody
  3. /Anti-Human Nicastrin (CT)
Product & ReviewsAntibodies

Anti-Human Nicastrin (CT)

Leinco Technologies
0.0/5.0
|0 Reviews|Write your own Review

Product Details

Cat. No.
N153
Clonality
Polyclonal
Host
Rabbit
Leinco Technologies

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Product Overview

Anti-Human Nicastrin (CT)

Leinco Technologies
0.0/5.0
|0 Reviews

Links

Leinco Technologies

Why request a quote through SelectScience?

  • EasyIt’s quick and simple to do
  • FastYour inquiry will be delivered straight to the manufacturer
  • FreeYou’re under no obligation
  • SecureWe only pass your details on to trusted suppliers at your request
  • Save timeSubmit your details once and make multiple inquiries

  • (Opens in new tab)
  • (Opens in new tab)
  • (Opens in new tab)
Fields & Topics
  • Life Sciences
  • Drug Discovery & Development
  • Clinical Diagnostics
  • Environmental
  • Materials
  • Food & Beverage
  • General Lab
  • Lab Automation
  • Lab Informatics
  • Separations
  • Spectroscopy
  • Forensics
  • Cannabis Testing
Products & Reviews
  • All Products & Reviews
  • All Antibodies & Reviews
  • Write a Review
News & Insights
  • News & Articles
  • Events & Summits
  • Webinars
  • Editorial features
  • Immersive Content
Resources
  • Applications & Methods
  • How-to-Buy eBooks
  • Videos
Sponsors / Client
  • Media Kit
  • Reviews Program
  • Insights for Marketers
  • Seal of Quality
  • Case Studies
  • Testimonials
  • Editorial & Production Guidelines
  • Terms & Conditions of Business
  • Data Sharing Annex
About us
  • About Us
  • Careers
  • Contact Us
  • Corporate Social Responsibility Statement

SelectScience Brands

The Scientists Channel Logo
Scientists Choice Awards Logo

Awards

Queens Awards for Enterprise Logo
UK Life Sciences Award Logo
  • Terms
  • Cookie Policy
  • Acceptable use policy
  • Privacy

© SelectScience 2025

Login

New to SelectScience?
Register for free today

  • Summary
  • Reviews

Description

Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease(1,2 for review). Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, γ-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the α and γ cleavage site) or the toxic Aβ amyloid peptide (from the β and γ cleavage site)(3). It is thought that accumulation of the Aβ peptide is the precursor to Alzheimer’s disease(4). Nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of Nicastrin expression results in mouse embryonic lethality(5).

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human
  • Conjugate: Purified No Carrier Protein
  • Gene: 23385

Handling

  • Quantity: 0.1 mg
  • Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Applications

  • Blocking (BA)
  • Immunoprecipitation (IP)
  • Western Blotting (WB)
Specificity rating
Sensitivity rating
Quality rating
Be the first to leave a review