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Monocyte chemoattractant protein-4 (MCP-4), also know as CCL13, is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. MCP-4 is a major chemoattractants for eosinophils, basophils monocytes and T lymphocytes. The MCP protein family bind to specific G-protein-coupled receptors, initiating a signal cascade within the cell1,2 MCP-4 can cause joint destruction in rheumatoid arthritis.3