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LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. LIFR is necessary for the proper development of motor neurons in brainstem nuclei and the spinal cord.1 LIFR is composed of a heterodimer LIFR alpha and GP130. LIFR alpha is a glycosylated variant of LIFR and is identical with M1 differentiation inducing activity.2