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Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.1 GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.2 GDF15 is predominantly expressed in the liver, with lower levels seen in some other tissues. Its expression in the liver is significantly up-regulated during injury of organs such as liver, kidney, heart and lung.1,2,3 GDF-15 is a promising new biomarker in idiopathic pulmonary arterial hypertension.4