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Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. D45/ICAD has been identified as inhibitor of caspase activated DNase D40/CAD. D45 related proteins CIDE-A and CIDE-B (for cell death-inducing D-like effector A and B) were recently identified.1 CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of D45/ICAD and D40/CAD.1,2 Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by D45. CIDE-A is a D45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-A is expressed in many tissues.