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Anti-Avidin antibodies have been widely used as amplifying reagents in immunohistochemistry, in situ hybridization, microarray assays, ELISAs, blots, and many other applications. Our antibodies to avidin are produced in goats using our highly purified avidin and isolated by affinity chromatography. Anti-Avidin does not bind streptavidin and Anti-Streptavidin does not recognize avidin. These antibodies provide opportunities to significantly amplify signals in many applications.