This antibody detects a monomorphic general framework determinant of HLA-DR Class II antigen. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
FLJ51114; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen DR alpha chain; HLA-DRA1; major histocompatibility complex class II DR alpha; MHC cell surface glycoprotein; MHC class II antigen DRA; MLRW
|Reactivity||Bovine, Cat (Feline), Human|
|Storage||Store at 4°C.|
|Buffer||10mM PBS and 0.05% BSA|
|Flow Cytometry (FC), Immunocytochemistry (ICC), SDS-PAGE (SDS-PAGE)|
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Member since: 2016
Application Area: Flow cytometry
"Antibody did what was intended. Was useful in showing MHCII+ cells in the sample."