High-resolution detection of DNA copy number and structural variants with novel ISH technology
09 Dec 2021

Introducing ACD's novel chromogenic in situ hybridization (ISH) DNAscope Assays for high-resolution detection of DNA copy number and structural variations. DNA ISH is a spatial profiling tool based on hybridizing labeled complementary probes to the target DNA inside the cell nucleus to visualize any genetic alterations in tissues.

In this expert webinar, learn how current limitations of the DNA ISH assay, such as limited morphological detail, difficult interpretation and low-resolution detection due to larger probe sizes are addressed by the new assay. The DNAscope chromogenic duplex (red/blue) staining allows researchers to use a standard bright field microscope to visualize and quantify gene copy number variations (amplifications/deletions) and gene rearrangements or fusions in tissues with spatial and morphological context at single-cell resolution.

Discover how these novel chromogenic ISH assays are designed to provide:

  • Spatial visualization of any DNA target: Proven “double-Z” probe design and the signal amplification system of RNAscope enables rapid and flexible probe development
  • Unparalleled performance in detecting small genomic regions and single-gene loci: Amplify target-specific signals, but not background noise from non-specific hybridization
  • Easy interpretation and high-throughput data analysis: Permanent chromogenic signal and superior morphological context

Advanced Cell Diagnostics