How controlled pore glass selection improves siRNA yield and manufacturing performance

Thursday, February 26 at 16:00 GMT | 17:00 CET | 11:00 EST | 8:00 PST

High‑quality siRNA synthesis depends on selecting the appropriate solid support. While multiple support chemistries are available, controlled pore glass (CPG) remains widely used for siRNA manufacturing due to its robustness, chemical compatibility, and established performance.

The structural complexity of siRNA compared with standard oligos makes it highly dependent on optimal surface area, loading, and pore size. These CPG characteristics directly influence coupling efficiency, reproducibility, and overall product quality. As a result, choosing the appropriate CPG is essential for achieving higher yields and scalable, consistent siRNA manufacturing, while suboptimal supports can introduce variability and limit performance.

In this SelectScience webinar, Dr. Catherine McKeen, Senior Director of R&D at LGC Biosearch Technologies, will discuss how rational selection and engineering of CPG can improve siRNA synthesis outcomes. Drawing on comparative synthesis and analytical data, Dr. McKeen will demonstrate how optimized pore architecture and controlled loading strategies of CPG can improve siRNA yield, enhance batch‑to‑batch consistency, enable scalable production, and reduce manufacturing costs, helping you build a more predictable and cost‑efficient siRNA synthesis workflow.

Key learning objectives

• Understand how CPG surface area, loading, and pore size influence siRNA synthesis yield, consistency, and achievable scale
• Learn how differences in CPG characteristics can impact crude and purified oligonucleotide productivity without changing impurity profiles
• Review comparative analytical data to assess yield and purity outcomes across different CPG types
• Gain practical insight into selecting CPG supports to improve process predictability and support more cost-efficient siRNA manufacturing

Who should attend?

• Scientists and process developers involved in siRNA synthesis and manufacturing looking to improve yield, consistency, and cost-efficiency in oligonucleotide workflows.

Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.

Webinar details

• Cost: Free to attend
• Location: Online
• Duration: 60 minutes

Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.