Tbx21 (T-beta) Knockout Rat by SAGE Labs

Manufacturer SAGE Labs
T-box transcription factor (TBX21) is a member of the T-box protein family, which shares a common DNA-binding domain. TBX21 plays a critical role in Th1 cell differentiation through stimulation of IFN γ. Due to a hypersensitive immune system, the Tbx21 (-/-) rat model is useful for studies of acute and chronic human asthma, Crohn’s disease, colitis, cancer metastasis, autoimmune disorders and inflammation.Tbx21 (T-beta) Knockout Rat Characteristics: Macrophages from homozygous knockout rats... Read more


Tbx21 (T-beta) Knockout Rat by SAGE Labs product image
Tbx21 (T-beta) Knockout Rat

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T-box transcription factor (TBX21) is a member of the T-box protein family, which shares a common DNA-binding domain. TBX21 plays a critical role in Th1 cell differentiation through stimulation of IFN γ.

Due to a hypersensitive immune system, the Tbx21 (-/-) rat model is useful for studies of acute and chronic human asthma, Crohn’s disease, colitis, cancer metastasis, autoimmune disorders and inflammation.


Tbx21 (T-beta) Knockout Rat Characteristics:

  • Macrophages from homozygous knockout rats demonstrate less Th1 response with less IFN-γ secretion after simulation with PMA
  • Homozygous knockout rats show decreased bone mass
  • Homozygous knockout rats show elevated serum alkaline phosphotase levels
  • Background Strain: Sprague-Dawley

Research Applications:

  • Rheumatoid arthritis
  • Inflammation/Autoimmune disorders
  • Asthma
  • Multiple sclerosis
  • Thrombosis/Cardiac fibrosis
  • Vascular defects
  • Platelet defects/Platelet aggregation
  • Renal dysplasia
  • Crohn's disease
  • Colitis