QTRam®

The QTRam^® is a portable Transmission Raman Spectrometer powered by our patent-pending, award-winning STRaman^® technology that allows for rapid and nondestructive quantitative analysis ideal for blend and content uniformity testing of finished products such as tablets and capsules.

Transmission Raman is an excellent means of rapid, nondestructive testing of content uniformity and of blend uniformity, required tests for solid dosage forms. The portable QTRam can be used for at-line quantitation of tablet composition, reducing the time and associated production delays that come from needing to submit samples to the laboratory for in-process and final product testing. Calibrations can be developed for multicompetent testing from a single Raman spectrum. The QTRam measurement of the intact samples has the advantage that solid state properties of the sample, including polymorphic form and crystallinity, can be measured in addition to the chemical composition.

The QTRam can be easily operated using 21CFR Part 11 compliant software for quantitative analysis on the inbuilt tablet computer, while the portable form factor allows users to use it for at-line analysis or in the lab.

Applications:

• Content uniformity - ensure the dosage uniformity of the API in solid dosage finished product including tablets, capsules, and gels
• Blend uniformity – assess adequacy of mixing to ensure blend uniformity and homogeneity
• Formulation development - support QbD initiatives in quantifying API and excipient concentrations in finished dosage forms
• Counterfeit detection – calculate API quantity to ensure correct drug and correct dosage