Prkdc Knockout Rat by SAGE Labs

Manufacturer SAGE Labs
The Prkdc gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). DNA-PK is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity. Mature B and T cells are critical components for an adaptive immune system. DNA-PK knockout rats have severe combined immunodeficiency (SCID) and lack of b... Read more


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Prkdc Knockout Rat

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The Prkdc gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK).

DNA-PK is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity.

Mature B and T cells are critical components for an adaptive immune system. DNA-PK knockout rats have severe combined immunodeficiency (SCID) and lack of both B and T cells, due to their V(D)J recombination defect.

Rats deficient in the Prkdc gene produce no mature B or T cells. This SCID rat is a useful model for cancer, xenografts, vaccine development, and autoimmune and infectious disease study.


Prkdc Knockout Rat Characteristics:

  • DNA-PK knockout rats have severe combined immunodeficiency (SCID) and lack of both B and T cells
  • Background Strain: Sprague-Dawley

Research Applications:

  • Xenograft
  • Cancer metastasis
  • Tumor growth