Pink1 (Park6) Knockout Rat by SAGE Labs
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase.
Mutations in Pink1 are implicated in early-onset Parkinson’s disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.Pink1 (Park6) Knockout Rat Characteristics:
Homozygous knockout rats exhibit complete loss of target prot... Read more