Oribit 16 by Nanion Technologies GmbH

The Orbit 16 is an automated bilayer workstation enabling the recording of 16 artificial lipid bilayers simultaneously. It allows low noise recordings at high bandwidth without the need for any additional equipment. 


Oribit 16 by Nanion Technologies GmbH product image
Oribit 16
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The Orbit 16 platform takes the pain out of bilayer painting and subsequent recordings as it enables fast and successful data generation thanks to the rapid automated formation of 16 bilayers at once and their subsequent fully parallel recording. 

The Orbit 16 is equipped with a dedicated low-noise 16 channel amplifier (Elements s.r.l.) by default enabling the convenient fully parallel recording of 16 bilayers at highest bandwidths. Furthermore, most commercially available amplifiers are compatible with the Orbit 16, including the 16-channel Triton amplifier from Tecella. For single channel amplifiers like the EPC-10 or Axopatch, the Orbit has a built-in multiplexer switchboard, allowing for recordings from the individual bilayers by automatically switching through the recording sites.

The recording module of the Orbit 16 is supporting Ionera's MECA 16 recording chips: Lipid bilayers are formed on an array of 4 x 4 circular microcavities in highly inert polymer. Each microcavity accomodates an individual integrated Ag/AgCl-electrode. The bilayers can be easily and repeatedly zapped and re-formed in an automated fashion. After bilayer formation ion channels or nanopores are reconstituted via self-insertion, proteoliposome fusion or dilution from detergent micelles.

Features:

  • Automated formation of 16 artificial lipid bilayers at the push of a button
  • Fully parallel low noise, high bandwidth recordings
  • Substantial data generation due to 16 simultaneous recordings
  • Low noise 16 channel amplifier or integration of external amplifier(s) possible
  • Dedicated comprehensive recording software included
  • Target molecules can be introduced directly or by fusion of (proteo-)liposomes
  • Analysis of ion channels: voltage and ligand gated, temperature sensitive
  • Analysis of nanopores, antimicrobial peptides, toxins and many more
  • Cost-efficient experiments with disposable MECA 16 chips