Liver-MPS 12 (LC12) Consumable Plates by CN Bio

In conjunction with the PhysioMimix™ OOC lab-benchtop ready microphysiological (MPS) system, MPS-LC12 consumable plates are used to culture advanced 3D in vitro organ-on-a-chip models that provide fast, accurate and clinically translatable human data for improving the predictability of drug discovery.

Arranged in a multi-well format, the MPS-LC12 consumable plate features 12 independent wells that represent mini bioreactors. Embedded into each well are three-dimensional scaffolds. During experiments, scaffolds are continually perfused by oxygen and nutrients in cell culture medium, creating the ideal culture conditions for 3D microtissue formation. For example, by co-culturing primary liver cells in MPS-LC12 consumable plates, it is possible to mimic the architecture of the human liver capillary bed under perfusion.

Validated applications for MPS-LC12 consumable plates include:

• Disease modeling: e.g. NAFLD/NASH, Hepatitis B, Breast cancer liver metastasis, DILI
• Toxicology 
• ADME
• Pharmacology 
• Immuno-oncology 
• Drug repurposing

MPS-LC12 consumable plates are:

• Suitable for organoids, spheroids, iPSCs, primary cells, immortalized cell lines and precision-cut tissue slices 
• For sole use with CN Bio’s PhysioMimix™ OOC lab-benchtop ready microphysiological (MPS) system. 
• Designed to support users transitioning from 2D cell culture into 3D microtissues via a familiar open-well plate-based format 
• PDMS-free, reducing non-specific binding for non-biased assessment of drug responses 

Contact CN Bio for more information about 3D in vitro models validated using MPS-LC12 consumable plates, or guidance designing your own bespoke tissue or organ mimics.