Ldlr Knockout Rat by SAGE Labs
The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels.
Ldlr Knockout Rat Characteristics:
This model possesses a 337 bp deletion and 4 bp insertion within Exon 4 on chromosome 8
Homozygous knockout rats display loss of LDLR protein via Western blot
Homozygous knockout rats have increased body weight as compared to wild type
Homozy... Read more