Ldlr Knockout Rat by SAGE Labs

Manufacturer SAGE Labs
The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels. Ldlr Knockout Rat Characteristics: This model possesses a 337 bp deletion and 4 bp insertion within Exon 4 on chromosome 8 Homozygous knockout rats display loss of LDLR protein via Western blot Homozygous knockout rats have increased body weight as compared to wild type Homozy... Read more


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Ldlr Knockout Rat

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The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels.


Ldlr Knockout Rat Characteristics:

  • This model possesses a 337 bp deletion and 4 bp insertion within Exon 4 on chromosome 8
  • Homozygous knockout rats display loss of LDLR protein via Western blot
  • Homozygous knockout rats have increased body weight as compared to wild type
  • Homozygous knockout rats show significantly elevated serum cholesterol levels
  • Background Strain: Sprague-Dawley

Research Applications:

  • Atherogenesis
  • Atherosclerosis
  • Hypertension
  • Insulin resistance
  • Lipoprotein/Cholesterol transportation
  • Metabolism (Triglyceride/Cholesterol)
  • Obesity
  • Type II diabetes