Eppendorf DASGIP® Parallel Bioreactor System

Managing the weight of bioprocessing data can often overwhelm laboratories, but effective data management is both achievable and critical to successful biopharmaceutical development.

This SelectScience application eBook highlights advanced instruments and digital tools that integrate seamlessly into laboratory infrastructure, enabling continuous monitoring and streamlined data management. With remote accessibility, these solutions empower scientists to maintain oversight and control of bioprocessing data beyond the physical lab environment.

Download this SelectScience guide to learn:

• How to conduct accurate and efficient real-time monitoring of Chinese hamster ovarian (CHO) cultivation using the BioNsight®
• Case studies using automated technologies for sampling CHO and E.coli cultures to understand growth conditions, and improve experimental throughput.
• The potential of Raman spectroscopy to accurately track critical process parameters

Resource details:

• Document type: SelectScience guide
• Page count: 49
• Read time: 72 mins
• Edition: 1st

Since the COVID-19 pandemic, pressure has increased to develop more products for treating unexpected viral diseases at reduced costs, under safe conditions and in a timely manner. Monoclonal antibodies (mAbs) may hold great promise to fill this gap as an addition to vaccines and anti-viral drugs. Eppendorf has curated a mAb workflow to increase reproducibility and productivity of mAb research and development process. Explore how you can optimize process development, scale up, and device management to maximize yields and prevent instrument downtime.

Bioprocess scale-up from small development scale to pilot and production scale is a fundamental part of process development in the biopharmaceutical industry.

In this application note, Eppendorf scaled up a CHO cell culture bioprocess from 1 L using a DASGIP® Parallel Bioreactor System to 5 L using a BioFlo® 320 Bioprocess Control Station.

In this application note, Eppendorf demonstrates the feasibility of running anaerobic fermentation using the DASbox® Mini Bioreactor System and DASGIP® Parallel Bioreactor for small scale applications.

In this application note, Eppendorf demonstrates the capability of fed-batch cell culture and the flexibility of the SciVario twin platform, including its capability to control two bioreactors in parallel or individually across a wide range of vessel sizes.

This executive summary explores the parameters that must be controlled for the most effective use of a stirred-tank bioreactor and describes a case study of an hiPSC-based drug-screening platform to identify modulators of cardiac hypertrophy.

In this poster, Eppendorf outlines a microbiome culture workflow covering the diverse culturing needs of gut microbes (including oxygen, pH, and temperature control) and the scalable bioprocess systems that are available for culture research to production.

Bioprocessing has been used for decades for industrial food and beverage production to improve product characteristics, ensure consistent quality, and reduce production costs from strain engineering, optimization of process parameters, handling of difficult process conditions, and more. In this white paper, Eppendorf tackles these challenges in food and feed applications, discussing how stirred-tank bioreactor systems have proven their value, offering online control of critical process parameters, and how parallel bioprocess systems help accelerate process development and maximize the reproducibility between runs.

In bioprocess development, the control of biomass-specific substrate uptake rates is a valuable tool to determine the optimal supply of nutrients and/or inducers. This application note presents the development of a biomass soft sensor based on readily-available measurements and process parameters.

Microbial bioprocesses can be controlled by the concentration of biomass and hence the uptake rate of nutrients. This application note describes a method for using soft sensors, integrated with Eppendorf bioprocess control software DASware control 5, to measure biomass concentration and control various substrate uptake rates in small-scale bioreactors. The results are fully scalable and applicable to industry, without the need for additional expensive measuring equipment.

Recognized by scientists worldwide for the second year running, Eppendorf again won the Reviewers' Choice Award for best customer service. Watch the video to discover Dr. Andreas Hochberger's thoughts on winning the award.

Download the microbiome workflow poster from Eppendorf

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