Cyclooxygenase (COX), also known as prostaglandin synthase (PHS) and prostaglandin endoperoxide synthetase (PES), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.
Rats deficient in COX1 can be used for studying inflammation, thrombosis, vascular defects, platelet defects and alterations in platelet aggregation.Cox1 Knockout Rat Characteristics:
Homozygous knockout rats exhibit complet... Read more
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Cox1 Knockout Rat
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Cyclooxygenase (COX), also known as prostaglandin synthase (PHS) and prostaglandin endoperoxide synthetase (PES), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.
Rats deficient in COX1 can be used for studying inflammation, thrombosis, vascular defects, platelet defects and alterations in platelet aggregation.
Cox1 Knockout Rat Characteristics:
- Homozygous knockout rats exhibit complete loss of COX1 protein via Western blot
- Background Strain: Sprague-Dawley
Research Applications:
- Rheumatoid arthritis
- Inflammation/Autoimmune disorders
- Asthma
- Multiple sclerosis
- Thrombosis/Cardiac fibrosis
- Vascular defects
- Platelet defects/Platelet aggregation
- Renal dysplasia
- Crohn’s disease
- Colitis
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