Cadence™ BioSMB PD System by Pall Life Sciences Products - Biopharmaceutical Division

Continuous Single-Use, Multi-Column Chromatography. Pall’s Cadence BioSMB platform is the first disposable flow path, continuous multi-column chromatography solution that is fully scalable from the Process Development (PD) laboratory to GMP manufacturing. The BioSMB system is specifically designed to allow users to convert an existing batch process into a continuous chromatography step without changing the chromatographic sorbent, buffer system or product quality assays.


Cadence™ BioSMB PD System by Pall Life Sciences Products - Biopharmaceutical Division product image
Cadence™ BioSMB PD System
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Continuous Single-Use, Multi-Column Chromatography.
Pall’s Cadence BioSMB platform is the first disposable flow path, continuous multi-column chromatography solution that is fully scalable from the Process Development (PD) laboratory to GMP manufacturing. The BioSMB system is specifically designed to allow users to convert an existing batch process into a continuous chromatography step without changing the chromatographic sorbent, buffer system or product quality assays. BioSMB technology provides process consistency across all scales – development, clinical and full production – and is also practical to implement in flexible, multi-product facilities.

  • Inherent unit operation efficiency of the Cadence BioSMB PD system reduces the cost of chromatographic media by up to 80% without changing either the sorbent or buffer used in the chromatographic process.
  • Entire chromatographic process can be conducted in a smaller system containing a fraction of the media and buffer that would be required in a standard batch process to produce the same amount of material.
  • Ability to use up to 16 columns increases specific productivity and application flexibility. Position of the buffer selection valve eliminates composition gradients and wash steps.