ApoE Knockout Rat by SAGE Labs

Manufacturer SAGE Labs
In vivo model for cardiovascular, alzheimer’s and other neurodegeneration studies. Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood.ApoE Knockout Rat Characteristics: 16 bp deletion within Exon 3 on chromosome 1 Homozygous knockouts exhibit complete los... Read more


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ApoE Knockout Rat

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In vivo model for cardiovascular, alzheimer’s and other neurodegeneration studies.

Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood.


ApoE Knockout Rat Characteristics:

  • 16 bp deletion within Exon 3 on chromosome 1
  • Homozygous knockouts exhibit complete loss of ApoE protein via Western blot
  • Administration of high fat diets to ApoE KO rats has resulted in significantly reduced lifespan.
  • SAGE Labs does not recommend administering high fat diets to ApoE KO rats.
  • At an early age (5- and 10-week-old), ApoE knockouts demonstrate significantly higher serum cholesterol
  • Background Strain: Sprague-Dawley

Research Applications:

  • Atherogenesis
  • Atherosclerosis
  • Hypertension
  • Insulin resistance
  • Lipoprotein/Cholesterol transportation
  • Metabolism (Triglyceride/Cholesterol)
  • Obesity
  • Type II diabetes