Akura™ Twin Microplate
Akura™ Twin Microplate enables organ-organ cross-talk with immune cells at scale. Liquid, cell and spheroid handling as well as readouts can be highly automated through the use of ist unique plate features and plate standards. The pack contains individually wrapped Akura™ Twin Microplates with black-walled body bonded to transparent, continuous, 188 µm COP membrane, ultra-low-attachment coated, sterile, includes lid.
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The Akura™ Microplate is based on the Akura™ 384 plate body, in which always two adjacent wells are connected by a 100-µm high, 1.6-mm wide microchannel resulting in 192 twin pairs per plate.
The Akura™ Twin Microplate is an assay plate for pre-formed spheroids. InSphero recommends Akura™ 96 and 384 Plates for the generation of spheroids and parallel transfer into the Akura™ Twin Microplate after quality control.
- Unique SureXchange™ ledge engineered prevents unintended spheroid and immune cell aspiration
- Cell-repellent properties at all surfaces of wells and microchannels for long-term non-adherent culturing of spheroids and suspension cells
- Superior high-content imaging quality with a continuous, flat-bottom, 188 μm COP membrane, and a black-walled body
Mitigation of liver toxicity with the Akura Twin Microplate
Liver toxicity refers to the adverse effects or damage caused to the liver due to exposure to certain substances or medications. InSphero explores a high-throughput platform assessing liver toxicity induced by therapeutic bispecific antibodies in co-culture with liver tumors. The Akura Twin™ Microplate utilizes accurate 3D liver microtissues alongside tumor co-culture models to simulate the tumor microenvironment, aiming to identify mitigation strategies for liver damage and evaluate tumor-killing efficacy. Results indicate the potential for this platform to mimic clinical scenarios, aiding in the screening and development of novel immunotherapies.
