Member since: 2021
Organization: SB Drug Discovery
Reliable, flexible and easy-to-use automated E'phys system! Highly recommended!
Application Area: Ion channel electrophysiology
"At SB Drug Discovery we have found the SyncroPatch to be an easy-to-use platform that has allowed us to quickly characterise a broad range of voltage-gated and fast ligand-gated ion channels while further improving our efficiency through increased automation. The flexibility offered by the SyncroPatch has enabled us to conduct complex screening assays designed to meet customer demands and expand our ion channel drug discovery capabilities."
Member since: 2020
Organization: University of Copenhagen
Great instrument that made my PhD research possible.
Application Area:Functional screening of ion channel variants (ASIC1a)
"I had the chance to use the SyncroPatch for parts of my PhD research, enabling the high-throughput functional characterization of over 300 different ASIC1a variants. Working with transiently transfected cells that were FACS-sorted before the patch-clamp experiments, I didn't expect perfect seals, but I still got good quality data and reproducible results that formed the basis for my PhD project. I measured CRCs for activation and steady-state desensitization, as well as peptide modulation of the channel, and got fantastic support from Søren Friis both with technical questions and assay design. The SyncroPatch and its software are easy to use and allow for versatile assay design. The team at Nanion goes out of their way to help with all questions and requests that come up, and they host fantastic user meetings for idea exchange. After four years using the SyncroPatch, I can highly recommend it."
The new SyncroPatch 384 is a revolutionary automated patch clamp system consisting of a patch clamp module integrated into the state-of-the-art pipetting robot Biomek i5. With 384 amplifier channels and a 384-pipetting head, all 384 cells are recorded in parallel, resulting in a throughput of 20,000 data points per day. With its ease-of-use and open design, the SyncroPatch 384 supports full automation and integration into HTS environments.
But the SyncroPatch 384 is more than a high throughput screening system and can be implemented into all your electrophysiology projects, whatever your throughput needs. The 32-well mode of operation is ideal for smaller screening projects and academic research and takes full advantage of the economical price of the NPC-384 chip. Choose the number of parallel recordings that you need in multiples of 32, you can use the remaining wells over several days. Alternatively, you can use the SyncroPatch 384 in unattended mode for fully automated experiments for over 8 hours.
The exceptional data quality and flexibility have made the SyncroPatch 384 the preferred 384-channel automated patch clamp system for global pharmaceutical companies, CROs and academic institutions alike.
Additional information about the SyncroPatch 384 can be found at: https://www.nanion.de/en/products/syncropatch-384.html