Product News: Waters introduces the new DESI source for the Xevo TQ Absolute system

Pharmaceutical development scientists will now be able to decide which drug candidates to investigate further and develop into marketable drugs quicker than ever before

05 Jun 2023

Waters Corporation has launched the industry's first targeted imaging mass spectrometer based on its Xevo TQ Absolute tandem quadrupole mass spectrometer, the most sensitive and compact mass spectrometer in its class. The new instrument combines the Waters DESI XS source with the Xevo TQ Absolute system and is five times more sensitive and five times faster than discovery-based imaging systems at precisely determining whether a particular small molecule drug product – and how much of it - reaches its intended target, such as a brain, liver, or lung, in a test subject.

Applications for direct-from-sample DESI/tandem quadrupole mass spectrometry include:

  • Elucidating drug distribution in tissue sections
  • Monitoring relevant biochemical pathways in toxicological studies
  • Classifying tissue and determining tumor margins

At this year's ASMS conference, Waters is also showcasing its PFAS analytical workflow based on the ultra-sensitive Xevo TQ Absolute mass spectrometer, chemistries, and software. The end-to-end UPLC-MS workflow allows laboratories worldwide to upgrade their capability and keep current with the latest regulatory requirements for measuring parts-per-quadrillion levels of PFAS in air, water, soil, and food.

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