Product News: Achieve fast and reliable detection of fully assembled AAV capsules with PROGEN Dip’n’Check AAV tests

The AAV lateral flow tests represent a quick in-process control suitable for crude lysate as well as purified AAV analysis within less than 20 minutes

25 Mar 2022

Adeno-Associated Virus (AAV) vectors have developed to be one of the most commonly used vectors for gene transfer, representing a promising therapeutic approach to target inherited, genetic diseases, and many others. The gene therapy community, attempting to find treatments for a variety of genetic disorders faces several obstacles such as meeting the requirements from regulatory authorities as well as the time pressure caused by the rapidly growing market. The limited availability of accurate and reliable methods represents one of the bottlenecks for the production and analytical characterization of gene therapy products.

PROGEN´s mission is to provide high-quality products that help advance new therapies and develop existing research processes safely, quickly, and affordably for the gene therapy community. For this reason, the PROGEN team developed the Dip´n´Check AAV kits, based on PROGEN’s expertise in AAV assay development and the urgent need for fast analytical methods in the growing field of AAV-based gene therapy.

The Dip´n´Check AAV lateral flow tests allow fast in-process control at every step of your process and can be used for the analysis of crude lysates as well as purified AAV samples. The kits have been developed by PROGEN based on its unique AAV particle antibodies which detect fully assembled AAV particles and allow the estimate of the actual AAV titer in your sample. These antibodies have widely been proven to be a suitable and reliable tool for the detection of intact AAV capsids.

The rapid, semi-quantitative analysis of the Dip´n´Check AAV kits facilitate the acceleration of decision processes and help save precious time and sample.

Decide early on which samples have the best prospects in the process and what kind of results to expect in less than 20 minutes by following the simple 3-step process:

  1. Prepare your sample by adding the included antibody solutions
  2. Incubate for 10 minutes
  3. Add the lateral flow test stripe and get your result in just 10 minutes

Increase the probability for success and establish how to proceed best in the process early on.

Key features:

  • Results in less than 20 minutes
  • Suitable for analyzing crude lysate and purified AAV samples
  • Ideal in-process control for purification processes for example
  • Pre-testing AAV concentrations for downstream analytics
  • Available for AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, and AAV9

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