Immunovia AB (publ) (“Immunovia”) have announced that, following the breakthrough news that was announced in June, additional, more detailed data of the optimization study will be presented at the PancreasFest 2019, July 24-26 in Pittsburgh, US.
The results demonstrated that the IMMray™ PanCan-d signature together with CA19-9 generated ROC AUC-values of 0.97, 0.98 and 0.96 when differentiating PDAC vs. non-PDAC symptomatic individuals, healthy controls and type II diabetes, respectively. Similar results were achieved for all stages of PDAC.
“We are very pleased with these outstanding results which we believe will be welcomed by clinicians as well. They show conclusively that IMMray™ PanCan-d, has the capacity to differentiate between symptomatic, non-PDAC individuals, including type II diabetes, and all different stages of PDAC. These findings have significant clinical implications for individuals attending primary and secondary care units with non-specific but concerning symptoms where PDAC may be suspected,” commented Mats Grahn, CEO Immunovia. “Being first in the world to show such result give us increased confidence as we work towards launching the first reliable blood-based test for early detection of PDAC and further applying the platform technology to other indications.”
The study collected and tested 937 patient samples from 150 PDAC (stage I-IV), 570 non-PDAC symptomatic individuals and 217 healthy individuals using IMMray™ PanCan–d in combination with CA19-9 ELISA assay.
To minimize confounding, pre-analytical variables, all patient samples were collected and processed using the same standard operating procedures, stored at -80°C and tested within a year after collection. Data analysis was performed using Immunovia software algorithms and accuracies, SVM ROC AUC-values, were determined for the different groups.
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