Method validation is critical to adoption of an analytical method, but how does one tackle it for direct mass spectrometry (DMS) techniques? In this webinar (the third in a four-part series), we answer this question in the context of selected ion flow tube mass spectrometry (SIFT-MS), the leading automated DMS technique for analysis of volatile compounds.
First, we will make a comparison of method development for SIFT-MS and conventional chromatographic techniques. Then, using a detailed case study on headspace analysis of volatiles in water, we will describe how to develop and validate a SIFT-MS method so that the data can be used to support regulatory requirements. This is achieved by applying a strategic approach in accordance with ICH Q2(R1) Guidelines. Finally, a second brief case study describes analysis of BTEX in soil following methanolic extraction. Note that a third case study – analysis of residual formaldehyde analysis in novel drug delivery devices – will be described in the final webinar in the series. The case studies demonstrate the efficient method development and validation (and high sample throughput) achievable using automated SIFT-MS.
Join Dr. Mark Perkins, Senior Applications Chemist at Anatune, and Dr. Vaughan Langford, Principle Scientist at Syft Technologies, to learn more about how SIFT-MS works, how it speeds up analysis, and how it can be validated successfully in accordance with ICH Q2(R1) Guidelines suitable for pharmaceutical applications such as regulatory submissions where GMP compliance is essential.
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This webinar will run on Tuesday, October 27, at:
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