The 19F-13C TROSY principle opens exciting opportunities to probe structure, dynamics and interactions in large biomolecular systems, in which the 19F-labels can be incorporated into either a protein or a nucleic acid residue. The fluorine atom is an extremely sensitive probe towards its chemical environment thanks to high CSA (chemical shift anisotropy); at the same time CSA also badly broadens the NMR-signals of 19F-labels in biomacromolecules. The so-called TROSY effect can be used to combat CSA and narrow the linewidth of the 19F-signals allowing their detection by solution-state high-resolution NMR spectroscopy.
In this SelectScience webinar, Prof. Haribabu Arthanari, Assistant Professor at Dana-Farber Cancer Institute, will discuss state-of-art NMR investigations of large biomolecules with selective 19F-labels and the use of high-sensitivity cryogenic NMR probes at high magnetic fields.
Who should attend?
Certificate of attendance
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This webinar will run on Wednesday, November 25, at:
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