Trending in Clinical Diagnostics: Wearable POC Tech & New Data on Immunotherapy Resistance

Don’t miss April’s highlights thanks to our regular monthly round-up of all the most popular stories and resources in the clinical science community

6 May 2019
Frankie MacDonald
Administrator / Office Personnel

Editorial article

Mass spec meets chemotherapy

In a collaboration between Waters and MD Anderson Cancer Center, scientists have used mass spectrometry imaging of singular chemotherapy molecules to map the spatial distribution and efficacy in tumors.

Reducing the burden on emergency departments

Ortho clinical diagnostics latest assay to receive CE approval, the VITROS High Sensitivity Troponin I Assay, could dramatically reduce turnaround time for cases of a suspected heart attack – reducing patient mortality and alleviating the burden on emergency departments.

The latest fashion in point of care: wearable devices

A recent study published in the journal PLOS ONE revealed how a novel, ultrasound-based wearable device could monitor the formation of thrombi in real time and provide active intervention at early-stage disease

A world’s first for digital droplet PCR technology

A ddPCR solution for oncology testing has received approval for clinical use, for the first time ever. The technology, developed by Bio-Rad, could transform the way we treat patients by enabling clinicians to monitor mutational burden in near real time, and respond to changes before the cancer progresses.

A complete guide to hematology testing technology

SelectScience editors compile the latest and greatest in clinical hematology. Discover the best automated analyzers and stainers that suit your laboratory’s needs, with top purchasing tips and expert advice, in this comprehensive downloadable guide.

'A billion people are living with infectious diseases'

When it comes to infectious disease, there is a considerable need for more accurate, treatment-guiding diagnostics to prevent spread, sepsis, and mortality. Recently receiving CE approval for its advanced diagnostic platform, Alinity™ m, Abbott Diagnostics hopes to address this shortfall and reduce the global burden of communicable diseases.

Combatting resistance to anti-PD-1 Immunotherapy

Many patients experience innate or acquired resistance to checkpoint inhibitors through largely unknown mechanisms. However, a new combination approach to therapy – developed by Syndax – could overcome histone deacetylase mediated resistance in melanoma, and potentially other solid tumors. The results reported so far are promising.

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HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Hematology Point of CareTroponinChemotherapyImmunotherapyImmunotherapy is a treatment approach that utilizes the body�s immune system to fight diseases, especially cancer. It includes therapies such as monoclonal antibodies, checkpoint inhibitors, and CAR-T cell therapy. Immunotherapy is a rapidly growing area of research in oncology and autoimmune diseases. Browse our peer-reviewed product directory to find the best immunotherapy tools, compare products, check reviews, and get pricing directly from manufacturers.Imaging Mass SpectrometryCancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.