Rapid high-throughput amino acid analysis of GLP-1 analogs
16 Oct 2025Due to increased demand for glucagon-like-peptide-1 (GLP-1) receptor agonist based drugs, manufacturers are continually looking for fast and reliable solutions to screen and evaluate products to ensure that they meet regulatory standards. Amino acid analysis is a quantitative approach to assess composition and optimize bioprocess parameters during drug production, but often require lengthy hydrolysis and derivatization steps.
In this study, a microwave-assisted UPLC™ workflow is demonstrated, designed to rapidly hydrolyze, label, and identify amino acids in GLP-1 analogs using Waters AccQ·Tag™ Ultra Chemistry Kit as a turnkey solution to expedite amino acid analysis of GLP-1 analogs.
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