Quality control of cell-free DNA samples analyzed with next-generation sequencing
21 Nov 2023Analysis of cfDNA can introduce challenges due to its low concentration and possible contamination from high-molecular-weight (HMW) DNA, both necessitating reliable quality control. In this application note, Agilent Technologies discusses how to assess the quality of cell-free DNA samples analyzed with next-generation sequencing (NGS). The Agilent TapeStation system is a vital quality control tool in NGS workflows. The TapeStation systems and cell-free DNA ScreenTape assay provide a %cfDNA quality metric for determining the quality of input cfDNA for downstream processes.
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4200 TapeStation Instrument
Agilent TechnologiesThe Agilent 4200 TapeStation system is an established automated electrophoresis tool for DNA and RNA sample quality control. Fully automated sample processing enables the unattended analysis of size, concentration and integrity. Choose any sample number between 1 and 96 and analyze at constant cost per sample.
DNA Analysis ScreenTape
Agilent TechnologiesDNA ScreenTape analysis provides a fast, automated, and flexible DNA electrophoresis solution for sample quality control, e.g in next-generation sequencing workflows. The DNA ScreenTape assays can separate DNA fragments and libraries up to 5000 base pairs in 1-2 minutes/sample.