Nicoya launches Alto Automation Suite to facilitate SPR integration into high-throughput biologics discovery workflows
Nicoya presented its new biosensor technology innovation at SLAS2025 International Conference & Exhibition
4 Feb 2025Nicoya® has launched the Alto Automation Suite™ for its flagship Alto™ Digital SPR™ system. The Alto is a surface plasmon resonance (SPR) platform that is fully compatible with standard lab automation, enabling thousands of samples per week to be run without human intervention.

A robotic arm retrieves the Alto Cartridge, filled with samples and reagents, from the Opentron Flex liquid handling platform and transfers it to the Nicoya Alto Digital SPR system.
The Alto Automation Suite features an API to allow scientists to program tasks for the Alto and to facilitate its integration with existing automated workflows, LIMS systems, and data pipelines. Nicoya has also partnered with Opentrons to offer pre-configured labware definitions and workflows to streamline cartridge preparation on the Opentrons Flex® liquid handling robot.
"With the rapid evolution of AI in protein design, it’s becoming increasingly important to streamline high-throughput biologics characterization by automating and integrating workflows via software and hardware,” said Ryan Denomme, CEO at Nicoya. “Incorporating SPR into these workflows has traditionally been a significant challenge. Conventional SPR systems are bulky, complex, and require constant manual intervention to keep buffers replenished and to change out sensor chips. With Alto’s compact, robot-compatible design, unique well-plate-based cartridges, and cloud-native software, we’ve eliminated these barriers, enabling 24/7 unattended SPR analysis.”
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