Kirin and Fujitsu elucidate a novel gut-brain axis mechanism of citicoline for the first time
5 Jan 2026
Kirin Holdings Company, Limited and Fujitsu Limited have jointly conducted research on food functionality simulation with the goal of creating new functionalities in food.
This research utilized quantitative systems pharmacology (QSP) models, one of the AI-driven digital transformation (DX) technologies for drug discovery, combined with real-world experimental validation. As a result, the study has, for the first time worldwide, identified a previously unknown mechanism within the gut-brain axis associated with citicoline, a compound known for its role in supporting cognitive health.
This finding was obtained by combining virtual subject simulations based on advanced QSP technologies developed by Fujitsu in collaboration with its partner Nova In Silico SAS (France) with cell-based experimental validation.
Conventional drug discovery has been time-consuming and costly, with limitations in improving confidence in demonstrating efficacy in humans. In recent years, the diversification of medical needs and stricter constraints on animal testing have further increased the demand for efficient R&D.
To address these challenges, the introduction of DX technologies utilizing AI and data science has been accelerating. In particular, virtual subject generation and in silico simulation enabled by DX technologies are expected to improve reliability in demonstrating efficacy in humans without animal testing, making their application in food functionality research highly promising.
This study represents a globally pioneering example of the full-scale application of DX technologies in food functionality research. It evaluated novel physiological functions of citicoline by combining AI-based prediction with experimental validation.
These findings are expected to accelerate the adoption of AI-driven DX technologies in health science and contribute significantly to realizing a society that promotes longevity and well-being through innovative food solutions.
Key findings
The study predicted, through AI-based analysis, that citicoline could activate neuronal signaling via the gut and validated this prediction in vitro. Furthermore, gut nerves are known to be closely interconnected with the brain. This research has elucidated part of the gut-brain mechanism of citicoline.
Future plans
This study represents a globally pioneering example of the full-scale application of DX technology in food functionality research. It provides insights that help elucidate new physiological functions of citicoline, which are essential for supporting brain function, thereby enhancing citicoline’s value as a functional ingredient for health.