Application Note: Utilization of the Labcyte MicroClime Environmental Lid to Reduce Edge Effects in a Cell-Based Proliferation Assay
5 November 2018

In this study, we demonstrate the benefit of utilizing the Labcyte MicroClime Environmental Lid to reduce edge effects in a functional cell-based assay by measuring the mitigation of evaporation of fluid in reaction wells. The value of using MicroClime Lids is shown for 384-well and 1536-well plates in both standard gravimetric QC assessments and functional cell based viability assays. The results demonstrate reduced evaporation, the ability to miniaturize and extend proliferation assays, while generating better growth rates, and higher quality data with reduced CV’s.