Using Laser Diffraction to Support Early Stage Product Development

This application note considers the use of the Mastersizer 3000 laser diffraction system as a particle characterization tool which can be used throughout a product’s development lifecycle. The Mastersizer 3000’s Hydro SV small volume dispersion unit is designed to enable measurements during early stage development, while the larger volume Hydro MV, Hydro EV and Hydro LV dispersion units are designed to measure larger samples as part of product scale-up and manufacturing. Two different materials are considered – a product with a coarse particle size and one with a finer particle size – representing different measurement challenges in terms of sampling and dispersion.