Application Note: The Benefits of Automated Water Immersion Lenses for High-Content Screening
26 May 2017

High-content screening (HCS) combines automated microscopy and multiparametric analysis of cellular events. Most HCS assays are based on fluorescence detection, whereby air is the typical objective medium. However, water has a higher refractive index and this application note demonstrates that water immersion objectives can provide significantly brighter images from typical HCS samples compared to air objectives.