SOLAμ for Pre-Analysis Sample Concentration
18 Sept 2014This application note demonstrates the use of Thermo Scientific™ SOLAμ™ SPE product to enhance sample pre-concentration prior to analysis. Additional benefits include reduced workflow and stability for analytes susceptible to loss or degradation during evaporation and reconstitution. The use of a Thermo Scientific™ Accucore™ HPLC column provided fast and efficient separation without the need for an ultra high pressure system. MS/MS detection was performed on a Thermo Scientific™ TSQ Vantage™ mass spectrometer.
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Thermo Scientific™ SOLAµ™ Solid Phase Extraction 96 Well Plates
Thermo Fisher ScientificRemove variability and optimize high throughput laboratory workflows. Thermo Scientific™ SOLAµ™Solid Phase Extraction (SPE) Well Plates are designed for bioanalytical and clinical research analysts who require cleaner, highly reproducible, and robust sample extraction using very low sample and solvent volumes in high throughput workflows. SOLAµ Well Plates achieve this due to the unique and award winning innovative frit-less SPE technology.Bioanalytical laboratories continue to drive to higher efficacy drugs and long acting formulations which require lower quantification limits. There is also the desire to take advantage of the replacement, refinement and reduction policy which is resulting in reduced animal model use. The growth of biopharmaceuticals also brings into consideration additional analytical issues such as solvation and non-specific binding.Features & Benefits: Processing of low sample volumes High sensitivity due to low elution volumes High reproducibility Low analytical sample failures Ease of use High throughput processing