Routine determination of trifluoroacetic acid (TFA) and difluoroacetic acid (DFA) in surface and drinking water by direct injection using UPLC-MS/MS

In this application note, Waters^™ demonstrates a direct injection UPLC-MS/MS method for the determination of trifluoroacetic acid (TFA) and difluoroacetic acid (DFA) in surface and drinking water. The method performance study was completed on an ACQUITY UPLC^™ I-Class PLUS System with a Xevo^™ TQ-XS and electrospray ion source combination using a Waters Atlantis^™ Premier BEH C18 AX Column. Samples were prepared by pipetting into a polypropylene injection vial and adding internal standard.